Women who smoke are at an increased risk of developing colorectal tumours, according to a new study.
Researchers from the Mayo Clinic in America found that that smoking puts older women at significant risk of losing DNA repair proteins that are critical for defending against the development of some colorectal cancers - a finding which may affect their life insurance policies.
Women who smoked were found to be lacking some or all of four proteins, known as DNA mismatch repair (MMR) proteins.
These proteins keep cells lining the colon and rectum healthy by recognising and repairing genetic damage as well as mistakes that occur during cell division.
The researchers also discovered a direct association between the number of cigarettes smoked daily by study participants and increased risk of developing these specific tumours.
"Our findings suggest that tumours may form because cells can't repair themselves from damage induced by smoking," Mayo gastroenterologist Dr Paul Limburg said.
The findings also could have other clinical implications regarding chemotherapy, as tumours that lack MMR proteins might respond differently to standard treatment regimes, he added.
The study is to be presented at the annual meeting of the American Association for Cancer Research.
According to Cancer Research UK, around 36,100 people are diagnosed with bowel cancer each year.
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